Snapshots of Science & Medicine
Social Impact Activity, Teacherís Edition
Animals, Viruses, Rights, and Wrongs
Prepared by Susan Eriksen, Teacher,
Westerly High School, Westerly, R.I.
Students will clarify and reinforce concepts of
immune-system function and organ transplantation through role-playing hypothetical situations involving xenotransplantation.
Scenarios handout for each student.
Students should read the ďResearch in the NewsĒ and
ďSocial ImpactĒ articles in the Xenotransplantation issue of Snapshots in Science & Medicine.
This activity challenges students to articulate different viewpoints
on issues concerning the ethics of xenotransplantation. After each student has a copy of the scenarios handout below, the activity can be run in several different ways:
1. Ask each student to speak as one of the characters extemporaneously for
2. Instruct students to write a script and read it before the class.
3. Allow two or three students to prepare collaboratively, then act out a
conversation as the characters in the scenario for 2 to 4 minutes.
4. After reading the scenario aloud, ask the class as a whole to continue
the story or conversation, with each student providing one sentence. Assign one student to record each personís contribution. Once the entire class has contributed, read back the entire piece, and ask students
to discuss it.
5. Have students
prepare a written responses to one or more of the scenarios.
Give students ample time to prepare their thoughts before speaking or writing. In all
cases students should use the starter sentences to begin their presentation.
Assessment: Xenotransplantation Social Impact Activity
Here is an assesment rubric you may find useful.
Assesment Criteria (1 point each)
_________Use of vocabulary (1 point for each word, anything over 5 points is bonus)
_________Staying in "character"
_________Speaking for 1 full minute
_________Continuous speaking (no long breaks)
_________Using concepts from class
_________Bonus point for not pre-writing
_________Total Points Earned
Suggested List of vocabulary
- acute rejection
- anti-rejection drugs
- animal species
- chimeric immune system
(The following Student Handout is available in a printer friendly and editiable format)
Two researchers are discussing whether to use chimpanzees or genetically engineered pigs as the source for organs for transplantation. Their experiments involve using the livers of these animals temporarily in humans as they wait for suitable human liver transplants. Researcher 1 wants to use chimpanzee livers. Researcher 2 wants to use livers from genetically engineered pigs.
The chimpanzee liver should reduce the risk of acute rejection because chimpanzees are more like humans.
Researcher 2: If the pigs have been genetically engineered so they no longer express some
foreign antigens, the risk of rejection is nearly the same as with a chimpanzee.
Three friends are discussing the possibility of using animals that are bred specifically as sources of organs for human transplants. Student 1 is a strong animal-rights advocate. Student 2 received a transplanted liver from an accident victim; he almost died while waiting for a donor organ. Student 3 thinks using pigs is acceptable but doesnít accept the use of chimpanzees or baboons.
You canít just ignore the fact that this treatment kills the donor animal.
Student 2: If I have to choose between an animalís life and my life, Iím going to choose me.
I donít mind sacrificing pigsóI had a ham sandwich for lunchóbut chimpanzees are too much like humans to sacrifice for their organs.
A transplant surgeon talking to a very sick heart-transplant patient proposes using a pigís heart temporarily in the patient while they wait for a donor-heart match. The patientís own heart is very weak and will probably fail before a suitable human donor can be found.
This is an extremely risky procedure, but unless we do something very soon, you will likely die.
I can accept risks to myself, but Iím not comfortable with the thought that I might pass on some unknown animal virus and perhaps hurt my family, or even other people Iíve never met.
A doctor is discussing an experimental treatment with her late-stage AIDS patient. The treatment involves replacing part of the patientís bone marrow with a baboonís bone marrow, in an attempt to give her a functioning immune system thatís resistant to HIV (the virus that causes AIDS).
Itís important that you understand the risks and potential benefits involved in this procedure.
Patient: I understand all that, but Iím not sure I can live knowing Iím part baboon.