Posted
Oct 26, 1998

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fMRI: Pictures of the Brain In Action



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Dyslexia Leaves Its Mark by Ruth Levy Guyer
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For a long time people with dyslexia were called dumb or lazy. New research shows that specific brain abnormalities lie at the heart of this learning disability.

During the first four months of life, the human brain is a very busy place. In fact, says Guinevere Eden, a neuroscientist at Georgetown University in Washington, D.C., so much is happening -- so many cells
  Reading head
 

 An fMRI image, showing orientation in human head.

growing, dividing, and firing, so many structures maturing and taking appropriate shapes, so many important connections being made -- that "it is almost surprising that you don't actually hear all the commotion inside the infant's head!"

All that brain development is what permits people eventually to read and dance, talk and throw a frisbee. But not everyone can perform all these activities correctly or with ease. Some people, for example, have difficulties reading. Many of them have a condition called developmental dyslexia. They can run into serious problems at school, at work, and in social situations, because reading is so important in everyday life.

Many people think that the only problem in dyslexia is that the affected person mistakes "was" for "saw" and "tip" for "pit." But dyslexia is more complicated than that. "There is a huge language component to dyslexia," in addition to troubles interpreting visual information says Eden. But, she adds, that is about the only thing that people interested in dyslexia agree upon.

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Children with dyslexia describe how the letters and words on the printed page seem to jump around, superimpose themselves on one another, become indistinguishable (b looks like d, for example), or in other ways prove unmanageable. "It's like the words are walking," said one child with dyslexia.

At the end of the 19th century, two doctors in Britain -- a physician working in a school and an eye doctor -- described a condition that they called "congenital word blindness." Children with the condition couldn't read, even though they were of normal intelligence. Soon, another eye doctor proposed that word blindness arose when the area of the brain that was responsible for the "visual memory of words" had not developed properly.

In 1928, Samuel Orton, a neurologist in Iowa, described 15 children who shared some unusual quirky characteristics. In addition to confusing the letter b with d and the letter p with q, some could read more easily if they held pages up to a mirror, and a few were rapid mirror writers. Orton was optimistic that many of the children could be taught to read with new methods that exploited their other senses -- touch and hearing -- which were not impaired. He suggested that this condition might develop when needed connections in the brain do not get made.


 
 

fMRI images of people with (bottom) and without (top) dyslexia, taken while looking at stationary patterns (left) or moving patterns (right) of dots.

The human brain consists of a patchwork of regions that carry out different activities. At least 32 regions (labeled with a "V") are thought to participate in vision. Region V5, for example, seems to be crucial for tracking moving objects; V1 and V2 recognize colors and patterns. A number of studies in recent years have targeted a visual pathway that includes V5 as a trouble zone in people with dyslexia.

In 1996, Eden and her coworkers at the National Institue of Mental Health (NIMH) in Bethesda, Md., (where she worked at the time) confirmed this association. They used a technique called functional magnetic resonance imaging (fMRI) to look at brain activities in men with dyslexia and in men with no known reading problems. (See sidebar "sb_fmri"). As test subjects watched moving dots march around a movie screen, V5 became active only in the brains of those who read normally; the movements did not trigger V5 activity in those with dyslexia. Next, subjects were shown motionless dots in various patterns. In this test, V1 and V2 glowed similarly in the brains of everyone, whether they were normal readers or had dyslexia.

Eden's dramatic pictures indicate that, indeed, V5 is not working the way it should in people with dyslexia. Can V5 inactivity account for the inability of these individuals to make sense of the flow of words on the written page, or are these independent phenomena?

V5 is part of a broader system that processes fast-moving objects. This system works in concert with
  Reading head

 

 fMRI images showing decreased activity in region V5 in people with dyslexia (right, white arrows)

systems that process patterns and colors to make vision possible. One interpretation of Eden's results is that a specific cell type in the movement tracking system develops abnormally in people with dyslexia. This might in turn cause the coordination of the tracking system with the rest of the visual system to be incomplete or offbeat in people with dyslexia, so that the handling of words is faulty. Whatever the cause of developmental dyslexia, the
|outcome is tortured or unsuccessful reading.

Developmental dyslexia is said to be an "unexpected" condition because the people with it are smart enough to read, and typically have had ample exposure to books and reading instruction. For some, the language difficulties are confined to reading. For others, writing, spelling, and speaking are also problematic. Most do not have wide-ranging developmental disabilities.
 
 

Neuroscience Researcher Guinevere Eden



Lots of people -- kids and adults with dyslexia, their friends and family members (many of whom also have dyslexia), educators, psychiatrists, physiologists, behavioral scientists, policy makers, neuropsychologists -- are interested in dyslexia. They want to know where the problems lie, why they develop, and what can be done about them. Eden and her coworkers now have provided an answer to one of the "wheres."

Additional Resources

For an overview of brain imaging techniques, click here. Or go here for a good overview of fMRI. For a more recent set of fMRI findings about dyslexia, click here.

The International Dyslexia Association has a website, and it sponsors a website called Teens vs. Dyslexia for (and entirely by) teens with dyslexia. For a good list of dyslexia links, click here.