Implementing the Module

The five lessons in this module are designed to be taught either in sequence for approximately two weeks (as a replacement for a part of the standard curriculum) or as individual lessons that support or enhance your treatment of specific concepts in high school biology. The following pages offer general suggestions about using these materials in the classroom; you will find specific suggestions in the procedures provided for each lesson.

What Are the Goals of the Module?

The Brain: Understanding Neurobiology Through the Study of Addiction is designed to help students develop the following major goals associated with scientific literacy:

• to understand some basic fundamentals about neurobiology and how drugs of abuse change the brain;
• to recognize that drug addiction is a treatable, chronic brain disease;
• to experience the process of scientific inquiry and develop an enhanced understanding of the nature and methods of science; and
• to appreciate the role of science in society and the relationship between basic science and human health.

What Are the Science Concepts and How Are They Connected?

The lessons presented in this module form a conceptual whole that will provide students with a fundamental knowledge of neurobiology, drug abuse, and drug addiction. Students begin by learning how different areas of the brain regulate specific functions, including feeling pleasure (The Brain: What's Going On in There?).

Students extend their understanding of the brain by learning how neurons in the brain relay information through electrical and chemical signals (Neurons, Brain Chemistry, and Neurotransmission). Once students understand how neurons communicate, they explore how drugs of abuse alter the function of the brain by disrupting the signaling process between neurons (Drugs Change the Way Neurons Communicate). Students can then apply their knowledge of how drugs act at the cellular level to understand that drug addiction is a brain disease that is signified by changes in the brain, some of which may persist a long time or may be permanent (Drug Abuse and Addiction). Finally, students consider how treatment for the disease of drug addiction compares with that for other chronic diseases (Drug Addiction Is a Disease—So What Do We Do about It?). The chart Conceptual Flow of the Lessons illustrates the sequence of major concepts addressed by the five lessons.

Conceptual Flow of the Lessons

Lesson	Learning Focus*	Major Concept
Lesson 1 The Brain: What's Going On in There?	Engage/Explore	Specific brain regions control specific brain functions.
Lesson 2 Neurons, Brain Chemistry, and Neurotransmission	Explore/Explain	Neurons convey information using electrical and chemical signals.
Lesson 3 Drugs Change the Way Neurons Communicate	Explain/Elaborate	Drugs affect the biology and chemistry of the brain.
Lesson 4 Drug Abuse and Addiction	Explain/Elaborate	Addiction is a brain disease.
Lesson 5 Drug Addiction Is a Disease—So What Do We Do about It?	Elaborate/Evaluate	Drug addiction is a recurring chronic disease that can be treated effectively, similar to other chronic diseases.

*See How Does the 5E Instructional Model Promote Active, Collaborative, Inquiry-Based Learning?

How Does the Module Correlate with the National Science Education Standards?

The Brain: Understanding Neurobiology Through the Study of Addiction supports teachers in their efforts to reform science education in the spirit of the National Research Council's 1996 National Science Education Standards (NSES). The content of the module is explicitly standards based: Each time a standard is addressed in a lesson, an icon appears in the margin and the applicable standard is identified. The chart Content Standards: Grades 9–12 lists the specific content standards that this module addresses.

Content Standards: Grades 9–12
Standard A: As a result of activities in grades 9–12, all students should develop	Correlation to The Brain: Understanding Neurobiology Through the Study of Addiction
Abilities necessary to do scientific inquiry
Identify questions and concepts that guide scientific investigations.	Lessons 1, 2, 3, 4, and 5
Design and conduct scientific investigations.	Lesson 3
Use technology and mathematics to improve investigations and communications.	Lessons 1, 2, 3, 4, and 5
Formulate and revise scientific explanations and models using logic and evidence.	Lessons 2, 3, 4, and 5
Recognize and analyze alternative explanations and models.	Lessons 1, 2, 3, and 4
Communicate and defend a scientific argument.	Lessons 1, 2, and 3
Use mathematics in all aspects of scientific inquiry.	Lesson 4
Understandings about scientific inquiry
Scientists rely on technology to enhance the gathering and manipulation of data.	Lessons 1 and 4
Mathematics is essential in scientific inquiry.	Lessons 3 and 4
Standard C: As a result of their activities in grades 9–12, all students should develop understanding of
The cell
Cells have particular structures that underlie their functions.	Lesson 2
Most cell functions involve chemical reactions.	Lesson 2
Cell functions are regulated.	Lessons 2 and 3
Cells can differentiate, and complex multicellular organisms are formed as a highly organized arrangement of differentiated cells.	Lessons 1 and 2
Behavior of organisms
Multicellular animals have nervous systems that generate behavior.	Lessons 1, 2, and 3
Organisms have behavioral responses to internal changes and to external stimuli.	Lessons 1, 2, and 3
Behavioral biology has implications for humans, as it provides links to psychology, sociology, and anthropology.	Lessons 4 and 5
Standard E: As a result of their activities in grades 9–12, all students should develop
Understandings about science and technology
Science often advances with the introduction of new technologies.	Lessons 1 and 4
Standard F: As a result of their activities in grades 9–12, all students should develop understanding of
Personal and community health
The severity of disease symptoms is dependent on many factors, such as human resistance and the virulence of the disease-producing organism.	Lessons 4 and 5
Personal choice concerning fitness and health involves multiple factors.	Lessons 4 and 5
An individual's mood and behavior may be modified by substances.	Lessons 1, 4, and 5
Families serve basic health needs, especially for young children.	Lesson 5
Standard G: As a result of their activities in grades 9–12, all students should develop understanding of
Nature of scientific knowledge
Because all scientific ideas depend on experimental and observational confirmation, all scientific knowledge is, in principle, subject to change as new evidence becomes available.	Lessons 1, 2, 3, 4, and 5
Historical perspectives
Usually, changes in science occur as small modifications in extant knowledge.	Lesson 1

Teaching Standards

The suggested teaching strategies in all the lessons support teachers as they work to meet the teaching standards outlined in the National Science Education Standards. The module helps teachers of science plan an inquiry-based science program by providing short-term objectives for students. It also includes planning tools such as the Conceptual Flow of the Lessons chart and the Suggested Timeline for teaching the module. Teachers can use this module to update their curriculum in response to their students' interest in this topic. The focus on active, collaborative, and inquiry-based learning helps teachers support the development of student understanding and nurture a community of science learners.

The structure of the lessons in this module enables teachers to guide and facilitate learning. All the activities encourage and support student inquiry, promote discourse among students, and challenge students to accept and share responsibility for their learning. The use of the 5E Instructional Model, combined with active, collaborative learning, allows teachers to respond effectively to the diversity of student backgrounds and learning styles. The module is fully annotated, with suggestions for how teachers can encourage and model the skills of scientific inquiry, as well as the curiosity, openness to new ideas and data, and skepticism that characterize science.

Assessment Standards

Teachers can engage in ongoing assessment of their teaching and of student learning using the variety of assessment components embedded within the module's structure. The assessment tasks are authentic: They are similar in form to tasks in which students will engage in their lives outside the classroom or in which scientists participate. Annotations guide teachers to these opportunities for assessment and provide answers to questions that can help teachers analyze student feedback.

How Does the 5E Instructional Model Promote Active, Collaborative, Inquiry-Based Learning?

Because learning does not occur through a process of passive absorption, the lessons in this module promote active learning: Students are involved in more than listening and reading. They are developing skills, analyzing and evaluating evidence, experiencing and discussing, and talking to their peers about their own understandings. Students work collaboratively with others to solve problems and plan investigations. Many students find that they learn better when they work with others in a collaborative environment than they can when they work alone in a competitive environment. When all this active, collaborative learning is directed toward inquiry science, students succeed in making their own discoveries. They ask questions, observe, analyze, explain, draw conclusions, and ask new questions. These inquiry experiences include both those that involve students in direct experimentation and those in which students develop explanations through critical and logical thinking.

This view of students as active thinkers who construct their own understanding out of interactions with phenomena, the environment, and other individuals is based on the theory of constructivism. A constructivist view of learning recognizes that students need time to

• express their current thinking;
• interact with objects, organisms, substances, and equipment to develop a range of experiences on which to base their thinking;
• reflect on their thinking by writing and expressing themselves and comparing what they think with what others think; and
• make connections between their learning experiences and the real world.

This module provides a built-in structure for creating a constructivist classroom: the 5E Instructional Model. This model sequences the learning experiences so that students have the opportunity to construct their understanding of a concept over time. The model takes students through five phases of learning that are easily described using five words that begin with the letter "E": Engage, Explore, Explain, Elaborate, and Evaluate. The following paragraphs illustrate how the 5Es are implemented across the lessons in this module.

Engage

Students come to learning situations with prior knowledge. This knowledge may or may not be congruent with the concepts presented in this module. The Engage lesson provides the opportunity for teachers to find out what students already know or what they think they know about the topic and concepts to be developed.

The Engage lesson in this module, Lesson 1, The Brain: What's Going On in There?, is designed to

• pique students' curiosity and generate interest,
• initiate students' thinking about the function of the brain,
• encourage students to compare their ideas with the ideas of others, and
• allow teachers to assess what students do or do not understand about the stated outcomes of the lesson.

Explore

In the Explore phase of the module, Lesson 1, The Brain: What's Going On in There?, and Lesson 2, Neurons, Brain Chemistry, and Neurotransmission, students explore the function of the brain both as a body organ and as a collection of interacting cells. The lessons provide a common set of experiences within which students can compare what they think about what they are observing and experiencing.

During the Explore phase of the lessons, students

• use their skills of observation, logic, and deduction to gain an understanding of the process by which neurons relay information;
• acquire a common set of experiences with their classmates so they can compare results and ideas; and
• observe, describe, record, compare, and share their ideas and experiences.

Explain

The Explain components of Lesson 2, Neurons, Brain Chemistry, and Neurotransmission, and Lesson 3, Drugs Change the Way Neurons Communicate, provide opportunities for students to connect their previous experiences and to begin to make conceptual sense of the main ideas of the module. This stage also allows for the introduction of formal language, scientific terms, and content information that might make students' previous experiences easier to describe and explain.

In the Explain lessons in this module, students

• explain concepts and ideas about neurotransmission;
• incorporate the correct scientific terminology into their explanations;
• add new information about the actions of drugs to their understanding of neurotransmission;
• revise their ideas;
• compare their current thinking with what they previously thought;
• listen to and compare others' explanations of their results with their own; and
• become involved in student-to-student discourse in which they explain their thinking to others and debate their ideas.

Elaborate

In Elaborate lessons, students apply or extend the concepts in new situations and relate their previous experiences to new ones.

In the Elaborate lessons in this module, parts of Lessons 3 and 4, Drugs Change the Way Neurons Communicate and Drug Abuse and Addiction, students

• add information about the effects of drugs to increase their understanding of neurotransmission;
• consider the factors, including physical, environmental, and social, that influence the outcome of an individual's drug abuse;
• connect ideas, solve problems, and apply their understanding in these new situations;
• draw reasonable conclusions from evidence and data;
• add depth to their understanding of concepts and processes; and
• communicate their understanding to others.

Evaluate

The Evaluate lesson is the final stage of the instructional model, but it only provides a "snapshot" of what the students understand and how far they have come from where they began. In reality, the evaluation of students' conceptual understanding and ability to use skills begins with the Engage lesson and continues throughout each stage of the model, as described in the following section. Combined with the students' written work and performance of tasks throughout the module, however, the Evaluate lesson can serve as a summative assessment of what students know and can do.

The Evaluate lesson in this module, Lesson 5, Drug Addiction Is a Disease—So What Do We Do about It?, provides opportunities for students to

• demonstrate what they understand about the function of the brain and the effects of drugs on that function;
• integrate information from the previous lessons to form a deeper understanding of both neurobiology and drug abuse;
• assess their own progress by comparing their current understanding with their prior knowledge;
• apply their knowledge to situations in the real world; and
• ask new questions that take them deeper into a concept or topic area.

To review the relationship of the 5E Instructional Model to the concepts presented in the module, see the chart Conceptual Flow of the Lessons.

When a teacher uses the 5E Instructional Model, he or she engages in practices that are very different from those of a traditional teacher. In response, students also participate in their learning in ways that are different from those seen in a traditional classroom. The charts What the Teacher Does and What the Students Do outline those differences.

What the Teacher Does

Stage of the Instructional Model	That Is Consistent with the 5E Instructional Model	That Is Inconsistent with the 5E Instructional Model
Engage	Piques students' curiosity and generates interest Determines students' current understanding (prior knowledge) of a concept or idea Invites students to express what they think Invites students to raise their own questions	Introduces vocabulary Explains concepts Provides definitions and answers Provides closure Discourages students' ideas and questions
Explore	Encourages student-to-student interaction Observes and listens to the students as they interact Asks probing questions to redirect the students' investigations when necessary Asks questions to help students make sense of their experiences Provides time for students to puzzle through problems	Provides answers Proceeds too rapidly for students to make sense of their experiences Provides closure Tells the students that they are wrong Gives information and facts that solve the problem Leads the students step-by-step to a solution
Explain	Encourages students to use their common experiences and data from the Engage and Explore lessons to develop explanations Asks questions that help students express understanding and explanations Requests justification (evidence) for students' explanations Provides time for students to compare their ideas with those of others and perhaps to revise their thinking Introduces terminology and alternative explanations after students express their ideas	Neglects to solicit students' explanations Ignores data and information students gathered from previous lessons Dismisses students' ideas Accepts explanations that are not supported by evidence Introduces unrelated concepts or skills
Elaborate	Focuses students' attention on conceptual connections between new and former experiences Encourages students to use what they have learned to explain a new event or idea Reinforces students' use of scientific terms and descriptions previously introduced Asks questions that help students draw reasonable conclusions from evidence and data	Neglects to help students connect new and former experiences Provides definitive answers Tells the students that they are wrong Leads students step-by-step to a solution
Evaluate	Observes and records as students demonstrate their understanding of concept(s) and performance of skills Provides time for students to compare their ideas with those of others and perhaps to revise their thinking Interviews students as a means of assessing their developing understanding Encourages students to assess their own progress	Tests vocabulary words, terms, and isolated facts Introduces new ideas or concepts Creates ambiguity Promotes open-ended discussion unrelated to the concept or skill

What the Students Do

Stage of the Instructional Model	That Is Consistent with the 5E Instructional Model	That Is Inconsistent with the 5E Instructional Model
Engage	Become interested in and curious about the concept/topic Express current understanding of a concept or idea Raise questions such as, What do I already know about this? What do I want to know about this? How could I find out?	Ask for the "right" answer Offer the "right" answer Insist on answers or explanations Seek closure
Explore	"Mess around" with materials and ideas Conduct investigations in which they observe, describe, and record data Try different ways to solve a problem or answer a question Acquire a common set of experiences so they can compare results and ideas Compare their ideas with those of others	Let others do the thinking and exploring (passive involvement) Work quietly with little or no interaction with others (only appropriate when exploring ideas or feelings) Stop with one solution Demand or seek closure
Explain	Explain concepts and ideas in their own words Base their explanations on evidence acquired during previous investigations Become involved in student-to-student conversations in which they debate their ideas Record their ideas and current understanding Reflect on and perhaps revise their ideas Express their ideas using appropriate scientific language Compare their ideas with what scientists know and understand	Propose explanations from "thin air" with no relationship to previous experiences Bring up irrelevant experiences and examples Accept explanations without justification Ignore or dismiss other plausible explanations Propose explanations without evidence to support their ideas
Elaborate	Make conceptual connections between new and former experiences Use what they have learned to explain a new object, event, organism, or idea Use scientific terms and descriptions Draw reasonable conclusions from evidence and data Communicate their understanding to others	Ignore previous information or evidence Draw conclusions from "thin air" Use terminology inappropriately and without understanding
Evaluate	Demonstrate what they understand about the concept(s) and how well they can implement a skill Compare their current thinking with that of others and perhaps revise their ideas Assess their own progress by comparing their current understanding with their prior knowledge Ask new questions that take them deeper into a concept or topic area	Disregard evidence or previously accepted explanations in drawing conclusions Offer only yes-or-no answers or memorized definitions or explanations as answers Fail to express satisfactory explanations in their own words Introduce new, irrelevant topics

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