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American Cancer Society, Cancer Reference Information. No date. Retrieved December 19, 2009, from http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_statistics.

Bell, P., and Linn, M.C. 2000. Scientific arguments as learning artifacts: Designing for learning from the Web with KIE. International Journal of Science Education, 22(8): 797–817.

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Borchers, M.T., Harris, N.L., Wesselkamper, S.C., Zhang, S., Chen, Y., Young, L., et al. 2006. The NKG2D-activating receptor mediates pulmonary clearance of Pseudomonas aeruginosa. Infection and Immunity, 74(5): 2578–2584.

Bransford, J.D., Brown, A.L., and Cocking, R.R. 2000. How People Learn: Brain, Mind, Experience, and School. Washington, DC: National Academy Press.

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Corrigan, P., Watson, A., Otey, E., Westbrook, A., Gardner, A., Lamb, T., et al. 2007. How do children stigmatize people with mental illness? Journal of Applied Social Psychology, 37(7): 1405–1417.

Coté, T. 2009. The State of the Orphan Drug Act. Presentation to the Institute of Medicine Committee on Accelerating Rare Diseases Research and Orphan Product Development, August 12. Washington, DC.

Cystic Fibrosis Foundation. 2008. Research Milestones. Retrieved August 9, 2010, from http://www.cff.org/research/ResearchMilestones/.

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Fanciulli, M., Norsworthy, P.J., Petretto, E., Dong, R., Harper, L., Kamesh, L., et al. 2007. FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific autoimmunity. Nature Genetics, 39: 721–723.

Faurisson, F. 2004. EurordisCare2: Survey of Diagnostic Delays, 8 Diseases, Europe. Retrieved August 6, 2010, from http://archive.eurodis.org/imprimer.php3?id_article=54.

Feinberg, A.P., and Williams, B.R. 2003. Wilms’ tumor as a model for cancer biology. Methods in Molecular Biology, 222: 239–248.

Freeman, J.L., Perry, G.H., Feuk, L., Redon, R., McCarrol, S.A., Altshuler, D.M., et al. 2006. Copy number variation: New insights in genome diversity. Genome Research, 16: 949–961.

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Geier, R., Blumenfeld, P.C., Marx, R.W., Krajcik, J.S., Fishman, B., Soloway, E., et al. 2008. Standardized test outcomes for students engaged in inquiry-based science curricula in the context of urban reform. Journal of Research in Science Teaching, 45: 922–939.

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Hickey, D.T., Kindfeld, A.C.H., Horwitz, P., and Christie, M.A. 1999. Advancing educational theory by enhancing practice in a technology supported genetics learning environment. Journal of Education, 181: 25–55.

Institute of Medicine, 2010. Rare Diseases and Orphan Products: Accelerating Research and Development. Washington, DC: National Academies Press.

International HapMap Consortium. 2005. A haplotype map of the human genome. Nature, 437: 1299–1320.

International HapMap Consortium. 2007. A second generation human haplotype map of over 3.1 million SNPs. Nature, 449: 851–862.

Kaback, M., Lim-Steele, J., Dabholkar, D., Brown, D., Levy, N., Zieger, K., et al. 1993. Tay-Sachs disease—carrier screening, prenatal diagnosis, and the molecular era: An international perspective, 1970–1993. Journal of the American Medical Association, 270(19): 2307–2315.

Krajcik, J., Blumenfeld, P.C., Marx, R.W., Bass, K.M., Fredricks, J., and Soloway, E. 1998. Inquiry in project-based science classrooms: Initial attempts by middle school students. The Journal of the Learning Sciences, 7(3–4): 313–350.

Kuhn, L., Kenyon, L., and Reiser, B.J. 2006. Fostering scientific argumentation by creating a need for students to attend to each other’s claims and evidence. In S.A. Barab, K.E. Hay, and D. Hickey (Eds.), Proceedings of the Seventh International Conference of the Learning Sciences (pp. 370–375). Mahwah, NJ: LEA.

Leukemia and Lymphoma Society. No date. Leukemia Facts and Statistics. Retrieved December 19, 2009, from http://www.leukemia-lymphoma.org/all_page.adp?item_id=9346.

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Lupski, J., and Stankiewicz, P. 2005. Genomic disorders: Molecular mechanisms for rearrangements and conveyed phenotypes. PLoS Genetics, 1(6): e49.

Lynch, S., Kuipers, J., Pyke, C., and Szesze, M. 2005. Examining the effects of a highly rated science curriculum unit on diverse students: Results from a planning grant. Journal of Research in Science Teaching, 42: 921–946.

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McKusick-Nathans Institute of Genetic Medicine and Johns Hopkins University. 2005. Online Mendelian Inheritance in Man. Bethesda, MD: National Center for Biotechnology Information, National Library of Medicine. Available at http://www.ncbi.nlm.nih.gov/omim/.

McNeill, K.L., and Krajcik, J. 2007. Instructional strategies to support students writing scientific explanations. In J. Luft, J. Gess-Newsome, and R. Bell (Eds.), Science as Inquiry in the Secondary Setting. Washington, DC: National Science Foundation.

Minner, D.D., Jurist Levy, A., and Jeanne Century, J. 2009. Inquiry-based science instruction—What is it and does it matter? Results from a research synthesis years 1984 to 2002. Journal of Research in Science Teaching, published online at Wiley InterScience (www.interscience.wiley.com).

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National Institutes of Health. 2010. Rare Diseases Clinical Research Network (fact sheet). Retrieved August 11, 2008, from http://www.nih.gov/about/researchresultsforthepublic/RareDiseasesCRN.pdf.

National Institutes of Health. 2008. Nocardia Infection. Retrieved August 20, 2010, from http://www.nlm.nih.gov/mdelineplus/ency/article/000679.htm.

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National Organization for Rare Disorders. No date. FDA Approves HDE for Rare Disorder of Placenta. Retrieved January 18, 2011, from http://www.rarediseases.org/news/FDA_approves_HDE.

National Organization for Rare Disorders. 2007, December 4. Testimony Submitted by the National Organization for Rare Disorders Before the Social Security Administration Public Hearing on Compassionate Allowances. Retrieved August 4, 2010, from http://www.ssa.gov/compassionateallowances/NORDTestimonyCompassionateAllowances 120407.pdf.

National Research Council. 1996. National Science Education Standards. Washington, DC: National Academies Press.

National Research Council. 2000. Inquiry and the National Science Education Standards: A Guide for Teaching and Learning. Washington, DC: National Academies Press.

Office of Rare Diseases Research. 2009. Office of rare diseases research brochure. Available at http://rarediseases.info.nih.gov/asp/resources/ord_brochure.html.

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Rados, C. 2003. Orphan products: Hope for people with rare diseases. FDA Consumer, 37(6). Retrieved July 31, 2008, from http://www.fda.gov/fdac/features/2003/603_orphan.html.

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Steele, A.D., Emsley, J.G., Ozdinler, P.H., Lindquist, S., and Macklin, J.D. 2006. Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proceedings of the National Academy of Sciences, USA, 103: 3416–3421.

Stefansson, H., Helgason, A., Thorleifsson, G., Steinthorsdottir, V., Masson, G., Barnard, J., et al. 2005. A common inversion under selection in Europeans. Nature Genetics, 37(4): 129–137.

Stranger, B.E., Forrest, M.S., Dunning, M., Ingle, C.E., Beazley, C., Thorne, N., et al. 2007. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science, 315(5813): 848–853.

University of Cincinnati. 2006, September 6. Environmental Toxins May Cause Body’s Defenses to Worsen Lung Disease (news release). Retrieved August 9, 2008, from http://healthnews.uc.edu/news/?/3111/.

Watson, A.C., Otey, E., Westbrook, A.L., Gardner, A.L., Lamb, T.A., Corrigan, P.W., et al. 2004. Changing middle schoolers’ attitudes about mental illness through education. Schizophrenia Bulletin, 30(3): 563–572.

Weiss, I.R., Pasley, J.D., Smith, P.S., Banilower, E.R., and Heck, D.J. 2003. Looking Inside the Classroom: A Study of K–12 Mathematics and Science Education in the U.S. Chapel Hill, NC: Horizon Research.

Wilson, C.D., Taylor, J.A., Kowalski, S.M., and Carlson, J. 2010. The relative effects and equity of inquiry-based and commonplace science teaching on students’ knowledge, reasoning, and argumentation. Journal of Research in Science Teaching, 47(3), 276–301.

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